If you know Rózsa's work then you know what this sounds like for the most part. The score is well known for its use of the theremin, however, which Rózsa had just incorporated into his orchestra with his previous film score, for Hitchcock's Spellbound.

The music for Spellbound is quite famous on its own and while The Lost Weekend is similar in many ways, it's a stronger score which exploits the theremin's unique sound in a more effective way.